… It can cause severe acute pneumonitis in some patients. We … severe gefitinib-induced
pneumonitis and that neutrophils played … of the neutrophil elastase inhibitor sivelestat on gefitinib-…

… It can cause severe acute pneumonitis in some patients. We … severe gefitinib-induced
pneumonitis and that neutrophils played … of the neutrophil elastase inhibitor sivelestat on gefitinib-…

… We previously 37 demonstrated that mice with naphthalene-induced airway epithelial
injury developed 38 severe gefitinib-induced pneumonitis and that neutrophils played …

… To elucidate the involvement of neutrophil elastase in acetaminophen-induced liver injury, …
specific neutrophil elastase inhibitor, sivelestat, in mice with acetaminophen-induced acute …

… Neutrophil elastase (NE), secreted by activated neutrophils, … prior to receiving the NE inhibitor
sivelestat, N-acetylcysteine (… and that inhibition with sivelestat ameliorates hepatic injury. …

… Sivelestat, which is another NE inhibitor, reduces lung injury and the … inhibitors, such as
alpha2-macroglobulin, the alpha-1 protease inhibitor, monocyte neutrophil elastase inhibitors, …

Excessive activation of neutrophils results in the release of neutrophil elastase (NE), which
leads to lung injury in severe pneumonia. Previously, we demonstrated a novel immune …

… Sivelestat was used a positive control in this study as it has … performed with sivelestat in
patients with acute respiratory distress … It has been shown that NE inhibition by sivelestat did not …

… severe gefitinib-induced pneumonitis and that neutrophil plays … the effects of neutrophil
elastase inhibitor sivelestat (ONO-… Sivelestat (150 mg/kg) was given intraperitoneally from day 1 …

… Following an incubation in normal serum to block nonspecific proteins, the sections were
incubated with antibodies specific for neutrophil elastase (1:50; Santa Cruz, USA), anti-PD …