Objective To study the prognostic value of neutrophil disorders in a retrospective cohort of
high-grade glioma patients receiving definitive concurrent temozolomide and radiation.
Materials and methods Clinical records of consecutive patients treated in our Institution
between January 2005 and December 2010 with concurrent temozolomide (75 mg/m 2
daily) and radiation were collected. The prognostic value of pretreatment neutrophilia on
survival, defined as a neutrophil count exceeding 7 G/L, was examined. Results We …

Results We identified 164 patients, median age was 60 years (range: 19-83). All were
treated with concurrent temozolomide-based chemoradiotherapy. Initial surgery was
achieved in most (75%), with resection> 90% in 55 patients. Total 151 patients (92%) had
glioblastoma, and 13 patients (8%) had WHO grade III glioma. Eighty-two patients (50%)
displayed baseline neutrophilia. Mean neutrophil count were comparable in patients with
grade III gliomas or glioblastomas: 7.0 vs. 7.3 G/L, respectively (p= 0.701). Neutrophilia was …