New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers
A clearer understanding of HIV-1 specific immune responses in highly-exposed, persistently
seronegative (HEPS) subjects is important in developing models of HIV-1 protective
immunity. HIV-1 specific cytotoxic T-lymphocytes (CTL) have been described in a cohort of
HEPS Kenyan sex workers, and recent work has further elucidated these responses. CTL
specific for HIV-1 Env were found in the blood of over half the sex workers meeting criteria
for HIV resistance, and in some women recognized unmapped epitopes. The proportion of …
seronegative (HEPS) subjects is important in developing models of HIV-1 protective
immunity. HIV-1 specific cytotoxic T-lymphocytes (CTL) have been described in a cohort of
HEPS Kenyan sex workers, and recent work has further elucidated these responses. CTL
specific for HIV-1 Env were found in the blood of over half the sex workers meeting criteria
for HIV resistance, and in some women recognized unmapped epitopes. The proportion of …
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