New insights into the role of perinatal HPA-axis dysregulation in postpartum depression
Abstract Postpartum depression affects 10–20% of women following birth and exerts
persisting adverse consequences on both mother and child. An incomplete understanding of
its etiology constitutes a barrier to early identification and treatment. It is likely that prenatal
hormone trajectories represent both markers of risk and also causal factors in the
development of postpartum depression. During pregnancy the maternal hypothalamic–
pituitary–adrenal axis undergoes dramatic alterations, due in large part, to the introduction of …
persisting adverse consequences on both mother and child. An incomplete understanding of
its etiology constitutes a barrier to early identification and treatment. It is likely that prenatal
hormone trajectories represent both markers of risk and also causal factors in the
development of postpartum depression. During pregnancy the maternal hypothalamic–
pituitary–adrenal axis undergoes dramatic alterations, due in large part, to the introduction of …
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