Surface-enhanced Raman scattering (SERS) microspectroscopy is a very promising label-
free, noncontact, and nondestructive method for real-time monitoring of extracellular matrix
(ECM) development and cell integration in scaffolds for tissue engineering. Here, we
prepare a new type of micrometer-sized SERS substrate, core–shell microparticles
composed of solid carbonate core coated with silver nanoparticles and polyhedral multishell
fullerene-like structure, astralen. Astralen has been assembled with polyallylamine …