New synthesis of 7-azabicyclo [2.2. 1] heptane-1-carboxylic acid
A Avenoza, C Cativiela, JH Busto… - Tetrahedron, 2001 - Elsevier
… This report describes a new synthetic route to 7-azabicyclo[2.2.1]heptane-1-carboxylic
acid (Ahc), a constrained proline analogue, in which the key step is the Diels–Alder reaction
using methyl 2-benzamidoacrylate as dienophile. … As part of our research project on the
synthesis of new non-proteinogenic and unusual α-amino acids, our interest in the amino
acids with 7-azabicyclo[2.2.1]heptane skeleton as conformationally restricted proline
analogues11., 12., 13. has prompted us to develop a new method to obtain the proline …
acid (Ahc), a constrained proline analogue, in which the key step is the Diels–Alder reaction
using methyl 2-benzamidoacrylate as dienophile. … As part of our research project on the
synthesis of new non-proteinogenic and unusual α-amino acids, our interest in the amino
acids with 7-azabicyclo[2.2.1]heptane skeleton as conformationally restricted proline
analogues11., 12., 13. has prompted us to develop a new method to obtain the proline …
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