New water-soluble copper (II) complexes with morpholine–thiosemicarbazone hybrids: Insights into the anticancer and antibacterial mode of action
K Ohui, E Afanasenko, F Bacher, RLX Ting… - Journal of medicinal …, 2018 - ACS Publications
Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu
(II) complexes [Cu (L 1–6) Cl](1–6) formed weak dimeric associates in the solid state, which
did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu (II)
complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition,
complexes 2–5 were found to specifically inhibit the growth of Gram-positive bacteria …
good-to-moderate solubility and stability in water were synthesized and characterized. Cu
(II) complexes [Cu (L 1–6) Cl](1–6) formed weak dimeric associates in the solid state, which
did not remain intact in solution as evidenced by ESI-MS. The lead proligands and Cu (II)
complexes displayed higher antiproliferative activity in cancer cells than triapine. In addition,
complexes 2–5 were found to specifically inhibit the growth of Gram-positive bacteria …
[PDF][PDF] New Water-Soluble Copper (II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
ET Cabra, O Domotor, NV May, D Darvasiova… - 5th EUCHEMS …, 2019 - core.ac.uk
… solubility and high cytotoxicity, we designed new (iso)thiosemicarbazone-morpholine
hybrids and their Cu(II) complexes. Notably, … Herein we report on the synthesis of water-soluble
proligands HL1‒6 and Cu(II) complexes 1‒6 (Chart …
hybrids and their Cu(II) complexes. Notably, … Herein we report on the synthesis of water-soluble
proligands HL1‒6 and Cu(II) complexes 1‒6 (Chart …
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