Nickel complexes as efficient catalysts in multicomponent synthesis of tetrahydropyridine derivatives

AN Yankin, MV Dmitriev - Synthetic Communications, 2020 - Taylor & Francis
AN Yankin, MV Dmitriev
Synthetic Communications, 2020Taylor & Francis
Ni (Salen) complexes as an efficient, homogeneous catalysts revealed a catalytic activity
toward the one-pot synthesis of tetrahydropyridine derivatives through the pseudo five-
component reactions of aromatic aldehydes, aromatic amines, and β-ketoesters in ethanol at
room temperature. Mild reaction conditions, good yields, high diastereoseletivity, operational
simplicity, and the absence of tedious separation procedures, clean reaction profiles, high
atom economy, inexpensive starting materials, and environmentally benign catalyst are the …
Abstract
Ni(Salen) complexes as an efficient, homogeneous catalysts revealed a catalytic activity toward the one-pot synthesis of tetrahydropyridine derivatives through the pseudo five-component reactions of aromatic aldehydes, aromatic amines, and β-ketoesters in ethanol at room temperature. Mild reaction conditions, good yields, high diastereoseletivity, operational simplicity, and the absence of tedious separation procedures, clean reaction profiles, high atom economy, inexpensive starting materials, and environmentally benign catalyst are the key advantages of the present MCRs protocol.
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