Over the last 30 years, non-operating room anesthesia (NORA) has grown from a minor portion of overall anesthesia cases to a substantial anesthesia workload. This shift presents the profession with several new challenges, especially during the pandemic era. Along with new sites, insufficient surveillance equipment, insufficient assisting personnel, unfamiliarity with procedures, complicated machinery, and a lack of expertise in the NORA suite, infection management practices must be standardised during the COVID time to avoid spread and contamination. Therefore, anesthesiologists must recognize possible risk factors during anesthesia in non-operating rooms and familiarize themselves with standards to improve safe practice, by utilizing detailed protocols for infection prevention and medical management, ensuring adequate personal protection equipment (PPE) supplies and training, forecasting demand, and prioritizing diagnosis. This review article emphasizes suggested guidelines for NORA during COVID time to improve patient outcomes and reduce adverse events.