Non-invasive real-time imaging of atherosclerosis in mice using ultrasound biomicroscopy
L Gan, J Grönros, U Hägg, J Wikström… - Atherosclerosis, 2007 - Elsevier
There are increasing needs to develop imaging techniques to study in vivo vascular
morphology and function in various mouse models of atherosclerosis. Using ultrasound
biomicroscopy (UBM), we developed and validated a new imaging protocol to follow lesion
progression in atherosclerotic mice. ApoE and LDL receptor double knockout mice (DKO)
with various degree of atherosclerosis and normal control mice were imaged at the level of
the ascending aorta using UBM. Average plaque thickness, as well as plaque area were …
morphology and function in various mouse models of atherosclerosis. Using ultrasound
biomicroscopy (UBM), we developed and validated a new imaging protocol to follow lesion
progression in atherosclerotic mice. ApoE and LDL receptor double knockout mice (DKO)
with various degree of atherosclerosis and normal control mice were imaged at the level of
the ascending aorta using UBM. Average plaque thickness, as well as plaque area were …
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