Inflammation and oxidative stress have been implicated as pathogenic mechanisms in
Parkinson's disease (PD). Evidence from in vitro and animal studies suggests a possible
protective role of nonsteroidal anti‐inflammatory drugs (NSAIDs), including aspirin. We
investigated the risk of PD associated with use of aspirin and nonaspirin NSAIDs in a
population‐based case‐control study among enrollees of Group Health Cooperative, a
health maintenance organization in the Seattle area. Subjects included 206 cases between …

Purpose Several studies have explored the impact of non-steroidal anti-inflammatory drugs
(NSAIDs) and the risk of Parkinson disease (PD). However, the extent to which NSAIDs may
increase or decrease the risk of PD remains unresolved. We, therefore, performed a meta-
analysis of relevant studies to quantify the magnitude of the association between NSAID use
and PD risk in the elderly population. Methods The electronic databases such as PubMed,
EMBASE, Scopus, Google Scholar, and Web of Science were used to search the relevant …