Non-stoichiometric carbamazepine cocrystal hydrates of 3, 4-/3, 5-dihydroxybenzoic acids: coformer–water exchange
Chemical Communications, 2023•pubs.rsc.org
The cocrystallisation of carbamazepine (CBZ) with 3, 4-/3, 5-dihydroxybenzoic acids
(34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water
molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation
between the mechanical properties of the CBZ–DHBA cocrystals with the amount of
coformer present.
(34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water
molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation
between the mechanical properties of the CBZ–DHBA cocrystals with the amount of
coformer present.
The cocrystallisation of carbamazepine (CBZ) with 3,4-/3,5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ–DHBA cocrystals with the amount of coformer present.
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