Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM
I Álvarez-Twose, R Zanotti… - Journal of allergy and …, 2014 - Elsevier
Background Indolent systemic mastocytosis (ISM) without skin lesions (ISMs−) shows a
higher prevalence in males, lower serum baseline tryptase levels, and KIT mutation more
frequently restricted to bone marrow (BM) mast cells (MCs) than ISM with skin lesions
(ISMs+). Interestingly, in almost one-half of ISMs− patients, MC-mediator release episodes
are triggered exclusively by insects. Objective We aimed to determine the clinical and
laboratory features of ISMs− associated with insect-induced anaphylaxis (insectISMs−) …
higher prevalence in males, lower serum baseline tryptase levels, and KIT mutation more
frequently restricted to bone marrow (BM) mast cells (MCs) than ISM with skin lesions
(ISMs+). Interestingly, in almost one-half of ISMs− patients, MC-mediator release episodes
are triggered exclusively by insects. Objective We aimed to determine the clinical and
laboratory features of ISMs− associated with insect-induced anaphylaxis (insectISMs−) …
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