An analytical solution for a dissipative cavity field interacting with two qubits (TQs) in presence of Kerr-like medium is obtained. The super-operator method is used to obtaining the field density matrix elements under the dispersive approximation. Linear entropy is calculated to determine the entanglement between the cavity field and the TQs. Moreover, the Wehrl entropy and Wehrl phase distribution are discussed to discover the nonclassicality dynamics of a dissipative cavity field. It is found that the Kerr medium and the dissipation reduce the generated quantum coherence due to the qubit–cavity interactions. It is possible to control the ability of cavity–qubit interactions to generate quantum coherence by the mean photon number of the initial coherent cavity state. Moreover, the nonclassicality of the initial coherent state reduces the dissipative and the Kerr medium effects.