… extended our understanding of noradrenergic pain modulatory mechanisms. The … of
noradrenergic pain regulatory mechanisms both in health and disease. Since the perception of pain …

… Thus, the noradrenergic system appears to modulate different components of the pain … the
data available regarding the noradrenergic system in relation to pain, particularly focusing on …

… α 2C -adrenoceptor in pain modulation is not yet quite clear. … The intrinsic noradrenergic
pain regulatory system in the … stimulus-evoked pain behavior in animals without sustained pain (…

… The noradrenergic innervation of the dorsal horn originates … Whereas noradrenergic axon
terminals innervate the cell … mechanism for noradrenergic modulation of neurotransmitter …

… all been suggested as possible sources of the spinal noradrenergic (NA) innervation involved
in the centrifugal modulation of spinal nociceptive transmission. Several lines of evidence …

… the fact that chronic pain is … noradrenergic input to the DRt occurs on nociceptive stimulation
in the spared nerve injury (SNI) model of neuropathic pain and contributes to increased pain …

… in the NRM and their role in the modulation of pain sensitivity. The results of these experiments
are … alpha-1 noradrenergic receptors may be involved in the modulation of nociception. …

… Taken together, these observations indicate an important serotonergic role for bidirectional
pain modulation. Descending noradrenergic pain modulation Descending noradrenergic …

… The NA neurons located in the A1 nucleus, part of the lateral reticular nucleus of the
ventrolateral medulla, constitute a second NA pain modulation system. Electrical or chemical …

… Therefore, we speculate that trigeminal nerve injury shifts pain modulation within the
noradrenergic LC–mPFC circuit from inhibition to excitation—that perhaps while the LC typically …