[HTML][HTML] Not exclusively tissue factor: neutrophil extracellular traps provide another link between chemotherapy and thrombosis
YW Van Den Berg, PH Reitsma - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
… For over a century we have known of the bidirectional interplay between coagulation and
malignancies [1]. Coagulation proteins may trigger cellular signaling pathways that promote
primary tumor growth, and the metastasis of circulating tumor cells is facilitated by fibrin and
activated platelets [2]. On the other hand, the blood coagulation balance of cancer patients is
often tilted in favour of venous thrombosis (VT), probably as a result of an altered expression
pattern of coagulation proteins [eg tissue factor (TF)], increased phosphatidylserine exposure on …
malignancies [1]. Coagulation proteins may trigger cellular signaling pathways that promote
primary tumor growth, and the metastasis of circulating tumor cells is facilitated by fibrin and
activated platelets [2]. On the other hand, the blood coagulation balance of cancer patients is
often tilted in favour of venous thrombosis (VT), probably as a result of an altered expression
pattern of coagulation proteins [eg tissue factor (TF)], increased phosphatidylserine exposure on …
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