… Ketolides represent a novel class of macrolide antibiotics that have received much attention
… for the first time that the antibacterial activity of a macrolide could be separated from its …

… Macrolide antibiotics have been very effective in the treatment of … , the ketolides derived
from erythromycin A, have been … Ketolides are a novel class of antibacterials derived from …

… that are derived chemically from the macrolides and have been developed for use … novel
alterations in the structure of this ketolide are related to its improved antimicrobial properties…

… two poor antibacterial 3-keto macrolides narbomycin 29 … of macrolides could be an innovative
starting point for further chemical modifications in order to increase the antibacterial activity …

… of ketolides has rekindled interest in macrolides, and recent efforts have also led to a novel
class of 4”-carbamates with activity … at C-3 is an essential component for antibacterial activity. …

… The novel ketolide HMR 3647 (formerly called RU 66647) … The activity of the ketolides against
macrolide-resistant … bacteriostatic activity and has a considerable postantibiotic effect (PAE)…

… of various macrolides and pristinamycin… novel series of 11,12-cyclo-substituted ketolides
synthesized by Roussel Uclaf (27). In this report, we describe the in vitro antibacterial properties …

… Using telithromycin as a template, several chemical modifications were made to investigate
the relative importance of positions 2, 3, and 6 for the overall antibacterial activity of ketolides …

… of the ketolides are the key groups to produce activity against … In addition to having good
antibacterial activity, the above … some novel structures of macrolide derivatives that are difficult …

… novel C 12 vinyl ketolides which possess potent in vitro and in vivo antibacterial properties
against macrolide-… We report herein on the preparation of a novel C 12 ethyl macrolide core, …