Novel Mitochondrial DNA Variations Associated with Coronary Artery Disease in Type 2 Diabetes from an Asian Indian Population
P Sreekanth, J Vusukamalla… - British Journal of …, 2015 - open.journal4submit.com
Background: Mitochondrial dysfunction leading to insulin resistance may contribute to
metabolic and cardiovascular abnormalities and subsequent increase in coronary artery
disease. Since mitochondria are involved in generation of ROS, we aimed to investigate the
association of mtDNA mutations with T2DM and CAD in our population. Methods: We
analyzed the complete mtDNA of South Indian subjects which included patients with
angiographically documented CAD [n= 120], subjects with Type 2 Diabetes Mellitus and …
metabolic and cardiovascular abnormalities and subsequent increase in coronary artery
disease. Since mitochondria are involved in generation of ROS, we aimed to investigate the
association of mtDNA mutations with T2DM and CAD in our population. Methods: We
analyzed the complete mtDNA of South Indian subjects which included patients with
angiographically documented CAD [n= 120], subjects with Type 2 Diabetes Mellitus and …
Novel mitochondrial DNA variations associated with coronary artery disease in Type 2 Diabetes from an Asian Indian population.
PS Patnam Sreekanth, JV Jyothi Vusukamalla… - 2015 - cabidigitallibrary.org
Background: Mitochondrial dysfunction leading to insulin resistance may contribute to
metabolic and cardiovascular abnormalities and subsequent increase in coronary artery
disease. Since mitochondria are involved in generation of ROS, we aimed to investigate the
association of mtDNA mutations with T2DM and CAD in our population. Methods: We
analyzed the complete mtDNA of South Indian subjects which included patients with
angiographically documented CAD [n= 120], subjects with Type 2 Diabetes Mellitus and …
metabolic and cardiovascular abnormalities and subsequent increase in coronary artery
disease. Since mitochondria are involved in generation of ROS, we aimed to investigate the
association of mtDNA mutations with T2DM and CAD in our population. Methods: We
analyzed the complete mtDNA of South Indian subjects which included patients with
angiographically documented CAD [n= 120], subjects with Type 2 Diabetes Mellitus and …
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