Novel anticancer fused pyrazole derivatives as EGFR and VEGFR-2 dual TK inhibitors
NM Saleh, MG El-Gazzar, HM Aly, RA Othman - Frontiers in chemistry, 2020 - frontiersin.org
EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very
important in tumor development as well as in angiogenesis and metastasis. In this work, 6-
amino-4-(2-bromophenyl)-3-methyl-1, 4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile 1 and
(E)-4-(2-Bromobenzylidene)-5-methyl-2, 4-dihydro-3H-pyrazol-3-one 11 were selected as
starting materials to synthesize different fused pyrazole derivatives; dihydropyrano [2, 3-c]
pyrazole 1, 2, 7–9, and 15, pyrazolo [4′, 3′: 5, 6] pyrano [2, 3-d] pyrimidine 3–6, pyrazolo …
important in tumor development as well as in angiogenesis and metastasis. In this work, 6-
amino-4-(2-bromophenyl)-3-methyl-1, 4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile 1 and
(E)-4-(2-Bromobenzylidene)-5-methyl-2, 4-dihydro-3H-pyrazol-3-one 11 were selected as
starting materials to synthesize different fused pyrazole derivatives; dihydropyrano [2, 3-c]
pyrazole 1, 2, 7–9, and 15, pyrazolo [4′, 3′: 5, 6] pyrano [2, 3-d] pyrimidine 3–6, pyrazolo …
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