Novel benzo chromene derivatives: Design, synthesis, molecular docking, cell cycle arrest, and apoptosis induction in human acute myeloid leukemia HL-60 cells
RH Abd El-Hameed, MS Mohamed… - Journal of Enzyme …, 2023 - Taylor & Francis
A series of benzo [h] chromenes, benzo [f] chromenes, and benzo [h] chromeno [2, 3-d]
pyrimidines were prepared. All the newly synthesised compounds were selected by National
Cancer Institute for single-dose testing against 60 cell lines. Benzo [h] chromenes 5a and 6a
showed promising anti-cancer activity and selected for the five-dose testing. Compounds 5a
and 6a suppressed cell growth in HL-60 by the induction of cell cycle arrest, which was
confirmed using flow cytometry and Annexin V-FITC/PI assays showed at the G1/S phase by …
pyrimidines were prepared. All the newly synthesised compounds were selected by National
Cancer Institute for single-dose testing against 60 cell lines. Benzo [h] chromenes 5a and 6a
showed promising anti-cancer activity and selected for the five-dose testing. Compounds 5a
and 6a suppressed cell growth in HL-60 by the induction of cell cycle arrest, which was
confirmed using flow cytometry and Annexin V-FITC/PI assays showed at the G1/S phase by …
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