Novel safety-catch linker and its application with a Ugi/De-BOC/Cyclization (UDC) strategy to access carboxylic acids, 1, 4-benzodiazepines, diketopiperazines …
C Hulme, J Peng, G Morton, JM Salvino, T Herpin… - Tetrahedron letters, 1998 - Elsevier
This communication reveals the synthesis and application of a novel resin bound isonitrile.
The resin is an example of a novel safety-catch linker which upon BOC-activation can be
resin cleaved with a variety of nucleophiles. Use of this polymer supported isonitrile in the
Ugi multi-component reaction (MCR), followed by resin clipping and cyclization allows
access to diverse arrays of 1, 4-benzodiazepine-2, 5-diones, diketopiperazines and
ketopiperazines respectively. The methoxide safety-catch clipping strategy and subsequent …
The resin is an example of a novel safety-catch linker which upon BOC-activation can be
resin cleaved with a variety of nucleophiles. Use of this polymer supported isonitrile in the
Ugi multi-component reaction (MCR), followed by resin clipping and cyclization allows
access to diverse arrays of 1, 4-benzodiazepine-2, 5-diones, diketopiperazines and
ketopiperazines respectively. The methoxide safety-catch clipping strategy and subsequent …
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