Endoglin, alias CD105, is a human membrane glycoprotein highly expressed in vascular
endothelial cells. It is involved in angiogenesis and angiogenesis-related diseases,
including the rare vascular pathology known as hereditary hemorrhagic telangiectasia type
1. Although endoglin acts as an accessory receptor for members of the transforming growth
factor-β family, in recent years, emerging evidence has shown a novel functional role for this
protein beyond the transforming growth factor-β system. In fact, endoglin has been found to …