Now you see me, now you don't: New approaches to sparing nonmalignant cells from CAR T cell therapies

NE Petty, J Thomas, S Radtke, HP Kiem - Med, 2023 - cell.com
Med, 2023cell.com
While new immunotherapies have revolutionized the field of oncology, they have been
limited by their inability to distinguish between cancerous cells and healthy HSPCs. Work by
Casirati et al. 1 and Wellhausen et al. 2 in epitope editing antigens commonly expressed on
AML and HSPCs has unlocked several new targets for immunotherapies.
While new immunotherapies have revolutionized the field of oncology, they have been limited by their inability to distinguish between cancerous cells and healthy HSPCs. Work by Casirati et al.1 and Wellhausen et al.2 in epitope editing antigens commonly expressed on AML and HSPCs has unlocked several new targets for immunotherapies.
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