Background Early diagnosis of leptospirosis may contribute to the effectiveness of
antimicrobial therapy and early outbreak recognition. Nucleic acid and antigen detection
tests have the potential for early diagnosis of leptospirosis. With this systematic review, we
assessed the sensitivity and specificity of nucleic acid and antigen detection tests.
Objectives To determine the diagnostic test accuracy of nucleic acid and antigen detection
tests for the diagnosis of human symptomatic leptospirosis.

Background: Early diagnosis of leptospirosis may contribute to the effectiveness of
antimicrobial therapy and early outbreak recognition. Nucleic acid and antigen detection
tests have the potential for early diagnosis of leptospirosis. With this systematic review, we
assessed the sensitivity and specificity of nucleic acid and antigen detection tests.
Objectives: To determine the diagnostic test accuracy of nucleic acid and antigen detection
tests for the diagnosis of human symptomatic leptospirosis. Search methods: We searched …