Pine Island Glacier, West Antarctica, is the largest Antarctic contributor to global sea-level rise and is vulnerable to rapid retreat, yet our knowledge of its deglacial history since the Last Glacial Maximum is based largely on marine sediments that record a retreat history ending in the early Holocene. Using a suite of ¹⁰Be exposure ages from onshore glacial deposits directly adjacent to Pine Island Glacier, we show that this major glacier thinned rapidly in the early to mid-Holocene. Our results indicate that Pine Island Glacier was at least 690 m thicker than present prior to ca. 8 ka. We infer that the rapid thinning detected at the site farthest downstream records the arrival and stabilization of the retreating grounding line at that site by 8–6 ka. By combining our exposure ages and the marine record, we extend knowledge of Pine Island Glacier retreat both spatially and temporally: to 50 km from the modern grounding line and to the mid-Holocene, providing a data set that is important for future numerical ice-sheet model validation.