Background Misoprostol is effective for ulcers associated with the use of nonsteroidal
antiinflammatory drugs (NSAIDs) but is often poorly tolerated because of diarrhea and
abdominal pain. We compared the efficacy of omeprazole and misoprostol in healing and
preventing ulcers associated with NSAIDs. Methods In a double-blind study, we randomly
assigned 935 patients who required continuous NSAID therapy and who had ulcers or more
than 10 erosions in the stomach or duodenum (or both) to receive 20 mg or 40 mg of …

HAWKEY, CHRISTOPHER J.; KARRASCH, JEFFREY A.; SZCZEPANSKI, LESZEK;
WALKER, DONALD G.; BARKUN, ALAN; SWANNELL, ANTHONY J.; YEOMANS, NEVILLE
D.; FOR THE OMEPRAZOLE VERSUS MISOPROSTOL FOR NSAID-INDUCED ULCER
MANAGEMENT (OMNIUM) STUDY GROUP