Oncocytic tumors are rare tumors that have been described in many organs throughout the
body, mainly in salivary, parathyroid, thyroid, and adrenal glands and in the kidney. A wide
spectrum of benign and malignant oncocytic tumors can arise in various organs of the
neuroendocrine system. They are usually defined as tumors that are composed
predominantly or exclusively of oncocytic cells. A majority of these tumors are benign;
however, in some endocrine organs such as the thyroid the diagnosis of oncocytic/Hürthle …

This paper reviews the pathologic features of lesions which are oncocytic and involve
classic endocrine organs. The history of the oncocytic cell, its morphologic and
ultrastructural features, and important immunohistochemical findings are reviewed.
Oncocytic proliferations including non-neoplastic and neoplastic of the thyroid, parathyroid,
adrenal (both cortex and medulla), and pituitary are described. Their clinical relevance,
functional capacity and capability, and where appropriate, prognostic implications are …