One-pot, one-step production of dietary nucleotides by magnetic biocatalysts

J Del Arco, S Martínez-Pascual, VJ Clemente-Suárez… - Catalysts, 2018 - mdpi.com
… wet biocatalyst activity… biocatalyst (negligible loss of activity at 60 C during 24 h; reusable
up to seven cycles). Finally, as proof of concept, the enzymatic production of dietary nucleotides

[图书][B] Enzymatic synthesis of nucleic acid derivatives by immobilized enzymes

J Fernández-Lucas, M Arroyo - 2018 - books.google.com
… of natural nucleosides and nucleotides [2]. As an alternative, … biocatalysts have been
successfully employed in the one-pot … successfully employed in the one-potone-step” synthesis of …

Sustainable production of nucleoside analogues by a high-efficient purine 2′-deoxyribosyltransferase immobilized onto Ni2+ chelate magnetic microparticles

J Del Arco, J Jordaan, V Moral-Dardé… - Bioresource …, 2019 - Elsevier
… develop a magnetic biocatalyst for customized production of … onto Ni 2+ chelate magnetic
iron oxide porous microparticles (… employed in the one-pot, one-step production of different …

One-Pot, One-Step Production of Dietary Nucleotides by Magnetic Biocatalysts

J Arco Arrieta, S Martínez Pascual… - 2018 - lareferencia.info
… best wet biocatalystbiocatalyst (negligible loss of activity at 60 ◦C during 24 h; reusable
up to seven cycles). Finally, as proof of concept, the enzymatic production of dietary nucleotides

Purine and pyrimidine salvage pathway in thermophiles: a valuable source of biocatalysts for the industrial production of nucleic acid derivatives

J Del Arco, J Fernández-Lucas - Applied microbiology and biotechnology, 2018 - Springer
… of nucleobase, nucleoside, or nucleotide analogs. Due to … They also have many advantages,
such as one-pot one-step … As observed, the thermal stability and reusability of magnetic

Magnetic micro-macro biocatalysts applied to industrial bioprocesses

J Del Arco, AR Alcántara, R Fernández-Lafuente… - Bioresource …, 2021 - Elsevier
magnetic biocatalyst offered great potential for the enzymatic production of dietary nucleotides
… at a later stage in the one-pot, one-step production of various therapeutic nucleosides, …

Magnetic multi-enzymatic system for cladribine manufacturing

G Cruz, LP Saiz, M Bilal, L Eltoukhy, C Loderer… - International Journal of …, 2022 - mdpi.com
… sequential action of two magnetic biocatalysts. For that purpose… successfully applied to the
one-pot synthesis of cladribine under … and nucleotides) is a clear example of how biocatalysis

Immobilized biocatalysts

P Grunwald - Catalysts, 2018 - mdpi.com
… -activated MagReSyn ® Amine magnetic iron-oxide porous microparticles (MTtHGXPRT)
by different strategies for the one-pot, one-step production of dietary nucleotides. The best …

Structural and functional characterization of thermostable biocatalysts for the synthesis of 6-aminopurine nucleoside-5′-monophospate analogues

J Del Arco, E Pérez, H Naitow, Y Matsuura… - Bioresource …, 2019 - Elsevier
… in the one-pot, one-step production of NMP analogues. … Nucleic acid components (nucleosides,
nucleotides and … to ensure biocatalyst stability, and both magnetic derivatives …

Sustainable synthesis of uridine-5′-monophosphate analogues by immobilized uracil phosphoribosyltransferase from Thermus thermophilus

J Del Arco, J Galindo, VJ Clemente-Suárez… - … et Biophysica Acta (BBA …, 2020 - Elsevier
… MTtUPRT was employed in the one-pot, one-step production … are converted to nucleotides
by intracellular phosphorylation … biocatalyst recovery by employing a magnetic field [19,20]. …