One-pot preparation of piperazines by regioselective ring-opening of non-activated arylaziridines
P Trinchera, B Musio, L Degennaro… - Organic & …, 2012 - pubs.rsc.org
Organic & Biomolecular Chemistry, 2012•pubs.rsc.org
Herein we report a new straightforward synthesis of cis and trans 2, 5-disubstituted N, N-
dialkylpiperazines, even in enantioenriched form, by reacting non-activated N-alkyl
arylaziridines in the presence of a catalytic amount of a Lewis acid. A stereochemical and
NMR investigation revealed useful mechanistic insights for this process.
dialkylpiperazines, even in enantioenriched form, by reacting non-activated N-alkyl
arylaziridines in the presence of a catalytic amount of a Lewis acid. A stereochemical and
NMR investigation revealed useful mechanistic insights for this process.
Herein we report a new straightforward synthesis of cis and trans 2,5-disubstituted N,N-dialkylpiperazines, even in enantioenriched form, by reacting non-activated N-alkyl arylaziridines in the presence of a catalytic amount of a Lewis acid. A stereochemical and NMR investigation revealed useful mechanistic insights for this process.
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