Ontogeny of alkaline phosphatase activity in infant intestines and breast milk
Background Necrotizing enterocolitis (NEC) is a devastating disease of intestinal
inflammation that primarily affects premature infants. A potential risk factor for necrotizing
enterocolitis is exposure of the premature neonatal intestine to environmental bacteria and
their proinflammatory products such as lipopolysaccharide. The metalloenzyme alkaline
phosphatase (ALP) has been shown to reduce lipopolysaccharide-mediated inflammation.
Additionally, premature rat pups have reduced alkaline phosphatase activity and expression …
inflammation that primarily affects premature infants. A potential risk factor for necrotizing
enterocolitis is exposure of the premature neonatal intestine to environmental bacteria and
their proinflammatory products such as lipopolysaccharide. The metalloenzyme alkaline
phosphatase (ALP) has been shown to reduce lipopolysaccharide-mediated inflammation.
Additionally, premature rat pups have reduced alkaline phosphatase activity and expression …
Ontogeny of alkaline phosphatase activity in infant intestines and breast milk.
YY Yang Ye, E Rader, M Peters-Carr, RC Bent… - 2019 - cabidigitallibrary.org
Background: Necrotizing enterocolitis (NEC) is a devastating disease of intestinal
inflammation that primarily affects premature infants. A potential risk factor for necrotizing
enterocolitis is exposure of the premature neonatal intestine to environmental bacteria and
their proinflammatory products such as lipopolysaccharide. The metalloenzyme alkaline
phosphatase (ALP) has been shown to reduce lipopolysaccharide-mediated inflammation.
Additionally, premature rat pups have reduced alkaline phosphatase activity and expression …
inflammation that primarily affects premature infants. A potential risk factor for necrotizing
enterocolitis is exposure of the premature neonatal intestine to environmental bacteria and
their proinflammatory products such as lipopolysaccharide. The metalloenzyme alkaline
phosphatase (ALP) has been shown to reduce lipopolysaccharide-mediated inflammation.
Additionally, premature rat pups have reduced alkaline phosphatase activity and expression …
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