Open Access (OA) is the new publishing model that allows unrestricted access and reuse of research outputs. OA accelerates discovery in the sense that researchers can freely read and build on new findings based on other research. While the public seems to welcome more involvement in OA among academics, many researchers are still discussing about the challenges they face when publishing with OA journals including the issue of article processing charge (APC) and the quality of these journals. This paper examines several aspects related to OA publications such as publication productivity, citation impact, subject coverage, and publishing cost of Universiti Sains Malaysia (USM) based on SCOPUS data from 2013 to 2015. The findings show that the School of Medical Sciences, Physics and Pharmacy dominated the OA publications. This indicates that science-based researchers are highly inclined towards publishing in OA when compared to non-science researchers. The top three OA journals in are Plos One (multidisciplinary), Acta Chrystallographica Section E (chemistry) and Electronic Journal of Geotechnical Engineering (engineering, geology). Most of the authors tend to publish in Q3 journals (43%), followed by Q2 (28%), Q1 (16%) and Q4 (13%). However, with regards to citation impact per paper (average), every paper in the Q1 journal received 6.25 citations, followed by Q2 (2.8 citations), Q3 (1.33 citations) and Q4 (0.87 citation). The APC of OA publication range from RM0 to RM15, 000 per paper. The study provides useful insights about OA publications of USM researchers which can guide other researchers who wish to engage with OA. Further studies should be conducted by interviewing authors to further explore the OA research funding and strategy in choosing OA journals to publish in and the motivation in publishing in OA.