… to occur in patients with chronic pain who receive high-dose opioid therapy. The aim of
current … effects of opioid therapy and to ensure careful follow-up and cessation of therapy if the …

… opioid regimens. This adverse selection may link these trends in use, abuse, and overdose.
Long-term opioid therapy … -wide treatment of chronic pain with long-term opioid therapy. The …

… the effectiveness and harms of opioid therapy for chronic pain. We updated a prior review
(19) and expanded on it by focusing on long-term benefits and harms of opioid therapy, risk for …

… , opioids can be used to treat chronic pain safely and effectively. Many questions remain,
but what this article presents is how opioids should be used to treat chronic pain considering …

… with the common classes of opioid agonists and partial agonists, … opioids, the risks of opioid
therapy, and the requirements for safe and effective use of opioids in acute and chronic pain. …

… The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review
… The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review …

… of opioid pharmacodynamics and may influence our approach to management of chronic
pain. … the context of our current understanding of opioids and our prescribing patterns so that …

… initiation and continuation of opioids in chronic pain treatment: When in the course of treatment
opioid therapy of non–cancer-related chronic pain should be considered, for what level of …

… In response to the opioid epidemic and new guidelines, many patients on high-dose long
term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a result, a …

… There is no validated tool to predict the risk of substance abuse in patients with chronic
pain being considered for opioid therapy [47]. Patients' self-report of drug use is frequently …