[HTML][HTML] Optical coherence tomography angiography monitors human cutaneous wound healing over time
Quantitative imaging in medicine and surgery, 2018•ncbi.nlm.nih.gov
Background In vivo imaging of the complex cascade of events known to be pivotal elements
in the healing of cutaneous wounds is a difficult but essential task. Current techniques are
highly invasive, or lack the level of vascular and structural detail required for accurate
evaluation, monitoring and treatment. We aimed to use an advanced optical coherence
tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high
resolution imaging of cutaneous wound healing. Methods We used a clinical prototype …
in the healing of cutaneous wounds is a difficult but essential task. Current techniques are
highly invasive, or lack the level of vascular and structural detail required for accurate
evaluation, monitoring and treatment. We aimed to use an advanced optical coherence
tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high
resolution imaging of cutaneous wound healing. Methods We used a clinical prototype …
Abstract
Background
In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the non-invasive, high resolution imaging of cutaneous wound healing.
Methods
We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework.
Results
We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing.
Conclusions
OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.
ncbi.nlm.nih.gov
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