Optimal vitamin D, calcitriol, and vitamin D analog replacement in chronic kidney disease: to D or not to D: that is the question
Current opinion in nephrology and hypertension, 2011•journals.lww.com
… These same abnormalities lead to secondary hyperparathyroidism for which the
administration of calcitriol or vitamin D analogs has been the mainstay of therapy for decades.
This review summarizes new trials of vitamin D, calcitriol, and its analogs over the last 2 years.
… Importantly, the term ‘activated vitamin D’ as a specific term used for calcitriol and its analogs
should not be used, because we now know that all forms of vitamin D have activity in vivo
because of the ability of cells to hydroxylate and degrade vitamin D in an autocrine manner. …
administration of calcitriol or vitamin D analogs has been the mainstay of therapy for decades.
This review summarizes new trials of vitamin D, calcitriol, and its analogs over the last 2 years.
… Importantly, the term ‘activated vitamin D’ as a specific term used for calcitriol and its analogs
should not be used, because we now know that all forms of vitamin D have activity in vivo
because of the ability of cells to hydroxylate and degrade vitamin D in an autocrine manner. …
Summary
Despite the physiologic importance of vitamin D in health and disease, more research is required to determine which vitamin D derivative is required for optimal health in CKD patients.
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