Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response
PJ Trivedi, T Bruns, A Cheung, KK Li, C Kittler… - Journal of …, 2014 - Elsevier
Background & Aims Outcomes in primary biliary cirrhosis (PBC) can be predicted by
biochemical response to ursodeoxycholic acid (UDCA). Such stratification inadequately
captures cirrhosis/portal hypertension, recognised factors associated with adverse events.
Methods We evaluated a cohort of PBC patients (n= 386) attending the Liver Unit in
Birmingham (derivation cohort), seeking to identify risk-variables associated with transplant-
free survival independent of UDCA-response. A validation cohort was provided through well …
biochemical response to ursodeoxycholic acid (UDCA). Such stratification inadequately
captures cirrhosis/portal hypertension, recognised factors associated with adverse events.
Methods We evaluated a cohort of PBC patients (n= 386) attending the Liver Unit in
Birmingham (derivation cohort), seeking to identify risk-variables associated with transplant-
free survival independent of UDCA-response. A validation cohort was provided through well …
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