Optimum duration of regimens for Helicobacter pylori eradication

Y Yuan, AC Ford, KJ Khan, JP Gisbert… - Cochrane Database …, 2013 - cochranelibrary.com
Y Yuan, AC Ford, KJ Khan, JP Gisbert, D Forman, GI Leontiadis, F Tse, X Calvet, C Fallone…
Cochrane Database of Systematic Reviews, 2013cochranelibrary.com
Background The optimal duration for Helicobacter pylori (H. pylori) eradication therapy is
controversial, with recommendations ranging from 7 to 14 days. Several systematic reviews
have attempted to address this issue but have given conflicting results and limited their
analysis to proton pump inhibitor (PPI), two antibiotics (PPI triple) therapy. We performed a
systematic review and meta‐analysis to investigate the optimal duration of multiple H. pylori
eradication regimens. Objectives The primary objective was to assess the relative …
Background
The optimal duration for Helicobacter pylori (H. pylori) eradication therapy is controversial, with recommendations ranging from 7 to 14 days. Several systematic reviews have attempted to address this issue but have given conflicting results and limited their analysis to proton pump inhibitor (PPI), two antibiotics (PPI triple) therapy. We performed a systematic review and meta‐analysis to investigate the optimal duration of multiple H. pylori eradication regimens.
Objectives
The primary objective was to assess the relative effectiveness of different durations (7, 10 or 14 days) of a variety of regimens for eradicating H. pylori. The primary outcome was H. pylori persistence. The secondary outcome was adverse events.
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