Optogenetic control of kinetochore function
… two important kinetochore functions: checkpoint signaling and molecular motor activity.
Overall, our findings establish a foundation for opotogenetic manipulation of kinetochores and …
Overall, our findings establish a foundation for opotogenetic manipulation of kinetochores and …
Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces
… by the forces exerted by kinetochore microtubules and polar ejection … kinetochore fibers
with bridging fibers in chromosome alignment is unknown. Here, we develop an optogenetic …
with bridging fibers in chromosome alignment is unknown. Here, we develop an optogenetic …
Optogenetic control of PRC1 reveals its role in kinetochore alignment at the metaphase plate
… by the forces exerted by kinetochore microtubules and polar ejection … kinetochore fibers
with bridging fibers in chromosome alignment is unknown. Here we develop an optogenetic …
with bridging fibers in chromosome alignment is unknown. Here we develop an optogenetic …
[PDF][PDF] Optogenetic control of PRC1 reveals that bridging fibers promote chromosome alignment by overlap length-dependent forces
… by the forces exerted by kinetochore microtubules and polar ejection … kinetochore fibers
with bridging fibers in chromosome alignment is unknown. Here we develop an optogenetic …
with bridging fibers in chromosome alignment is unknown. Here we develop an optogenetic …
Lights, cytoskeleton, action: Optogenetic control of cell dynamics
T Wittmann, A Dema, J van Haren - Current Opinion in Cell Biology, 2020 - Elsevier
… protein functions in living cells. We provide a brief overview of various types of optogenetic
switches. We then discuss how diverse approaches have been used to control cytoskeleton …
switches. We then discuss how diverse approaches have been used to control cytoskeleton …
[HTML][HTML] Opto-katanin, an optogenetic tool for localized, microtubule disassembly
… Since p60-severing activity depends on its recruitment to microtubules, we considered
this enzyme to be a promising candidate for an optogenetic tool. We tested an assortment of …
this enzyme to be a promising candidate for an optogenetic tool. We tested an assortment of …
Optogenetic rescue of a patterning mutant
HE Johnson, NJV Djabrayan, SY Shvartsman… - Current Biology, 2020 - cell.com
… Here, we demonstrate exactly this capability by combining optogenetic control of Ras/extracellular
signal-related kinase (ERK) signaling with the genetic loss of the receptor tyrosine-…
signal-related kinase (ERK) signaling with the genetic loss of the receptor tyrosine-…
Optogenetic reversible knocksideways, laser ablation, and photoactivation on the mitotic spindle in human cells
… Thus, our approach of optogenetic control of Kif18A localization led to association of …
the optogenetic knocksideways, we can study the dynamics of the cut kinetochore fibers …
the optogenetic knocksideways, we can study the dynamics of the cut kinetochore fibers …
Optogenetic control of mitosis with photocaged chemical dimerizers
… We describe an optogenetic platform, based on photosensitive chemical inducers of dimerization,
which provides control over dimerization of … Optogenetic control of kinetochore function …
which provides control over dimerization of … Optogenetic control of kinetochore function …
Optogenetic EB1 inactivation shortens metaphase spindles by disrupting cortical force-producing interactions with astral microtubules
A Dema, J van Haren, T Wittmann - Current Biology, 2022 - cell.com
… Different microtubule populations contribute to spindle function: kinetochore microtubules
attach and transmit forces to chromosomes, … Optogenetic control of microtubule dynamics. …
attach and transmit forces to chromosomes, … Optogenetic control of microtubule dynamics. …
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