The authorized monitoring of life-supporting human organs and its supply chain is a complex procedure during the course of life. It is a resource sequence tour and an essential post-donor assessment from the beginning of the pre-evaluation of organ transplantation. Organ transplantation has made remarkable progress in improving surgical procedures; patient immunity with medicine and organ preservation has developed into a vital way of managing serious organ failure in the world. However, these advancements are unfit to mitigate the deficiencies of organ availability for needy patients. Due to the uneven demand-supply ratio of donors and patients, the patients are required to wait for longer durations. As per organ donation statistics, around 20 individuals lose their lives every day while waiting to receive an organ transplant offer. This emphasizes the transparency in the organ donation system. In this work, we have discussed the individualistic challenges in successful development of organ donation and transplantation systems worldwide, which includes legal and regulatory policies, insufficient infrastructure and equipment, and lack of coordination and management among the government authorities and medico-legal firms. However, organ donation and transplantation carry lots of opportunities that, if channeled perfectly, can enhance healthcare facilities. With the daily widening financial gap among emerging and advanced countries, the requirement of organs from underdeveloped countries for advanced countries is continuously expanding. This has heightened the risk of unethical trading in human organs for financial gain. Despite governments’ efforts to formalize the rules on donations of organs to avert misuse of donors, it is necessary that an organizational management and allocation system be secured, perceptible, and dispersed. This work discusses the role of a blockchain-specific approach for the prevention or monitoring of organ trafficking of authorized organ donors and beneficiaries by auditable medical transactions. This will open up a new area of blockchain-based smart health services to protect medical professionals and patients’ rights.