Aims The aims of this study were (i) to conduct a comprehensive systematic review of the
literature on the outcome of primary (initial or first time) root canal treatment;(ii) to investigate
the influence of some study characteristics on the estimated pooled success rates.
Methodology Longitudinal clinical studies investigating outcome of primary root canal
treatment, published up to the end of 2002, were identified electronically (MEDLINE and
Cochrane database 1966–2002 December, week 4). Four journals (International …

Aims (i) To carry out meta‐analyses to quantify the influence of the clinical factors on the
efficacy of primary root canal treatment and (ii) to identify the best treatment protocol based
on the current evidence. Methodology The evidence for the effect of each clinical factor on
the success rate (SR) of primary root canal treatment was gathered in three different ways:(i)
intuitive synthesis of reported findings from individual studies;(ii) weighted pooled SR by
each factor under investigation was estimated using random‐effect meta‐analysis;(iii) …