Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury.

MS Marber, R Mestril, SH Chi… - The Journal of …, 1995 - Am Soc Clin Investig
… body heat stress. Circumstantial evidence suggests that an inducible 70-kD heat shock
protein (hsp70i), increased markedly by whole body heat stress, contributes to the protection. …

Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning

EH Miyabara, JL Martin, TM Griffin… - … of Physiology-Cell …, 2006 - journals.physiology.org
… In brief, the rat HSP70 was cloned into pCAGGS, a vector … that overexpression of HSP70
protein in transgenic mice leads to … -overexpressing mice, radicicol, which quickly increases the …

Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo

JJ Hutter, R Mestril, EKW Tam, RE Sievers… - Circulation, 1996 - Am Heart Assoc
… were generated by use of a chimeric transgene that consisted of the rat inducible HSP72
gene inserted into the pCAGGS vector, which is under the control of the human …

Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction

S Rajdev, K Hara, Y Kokubo, R Mestril… - Annals of Neurology …, 2000 - Wiley Online Library
Increased expression of heat shock protein 70 (HSP70) in the brain has been extensively …
The heat shock proteins (HSPs), including HSP70, an inducible isoform of the 70-kd family, are …

… of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model

JM Hollander, JL Martin, DD Belke, BT Scott… - Circulation, 2004 - Am Heart Assoc
… Background— The small heat shock protein 27 (hsp27) increasesoverexpression of wild-type
hsp27 or a nonphosphorylatable hsp27 mutant was equally capable of protecting adult rat

Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy

EH Miyabara, TL Nascimento, DC Rodrigues… - … -European Journal of …, 2012 - Springer
increased morbidity and mortality [3]. The present study shows that the overexpression of
inducible HSP70 in transgenic mice … -mediated overexpression of HSP70 in muscles from rats

… of the 70-kD heat stress proteins by the tyrosine kinase inhibitor herbimycin-A protects rat neonatal cardiomyocytes. A new pharmacological route to stress protein …

SD Morris, DV Cumming, DS Latchman… - The Journal of …, 1996 - Am Soc Clin Investig
… a correlation between 70-kD hsp induction and tolerance against lethal heat stress and …
Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases

In vivo gene transfection with heat shock protein 70 enhances myocardial tolerance to ischemia-reperfusion injury in rat.

K Suzuki, Y Sawa, Y Kaneda… - The Journal of …, 1997 - Am Soc Clin Investig
… the stresses such as heat or ischemia also induce the increase in some other cytoprotective
… an analysis using transgenic mice overexpressing HSP70 (30, 31). In a transgenic animal, …

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.

JC Plumier, BM Ross, RW Currie… - The Journal of …, 1995 - Am Soc Clin Investig
Overexpression of the human HSP70 does not appearto … anti-human inducible 70-kD heat
shock protein antibody. The … Expression of inducible stress protein 70 in rat heart myogenic …

Induction of heat shock proteins for protection against oxidative stress

B Kalmar, L Greensmith - Advanced drug delivery reviews, 2009 - Elsevier
… in transgenic mice that overexpress Hsp70, although these … The inducible isoform of heme
oxygenase, inducible heme … In these rats, both Hsp27 and Hsp70 levels were significantly …