Intracerebroventricular administration of oxytocin (OT) and an OT agonist significantly
decreased food intake in a dose-related manner in fasted rats. Central administration of an
OT antagonist by itself (up to doses of 8 nmol) did not potentiate deprivation-induced food
intake, but pretreatment with the OT receptor antagonist prevented the expected inhibition of
food intake produced by OT and the OT agonist. Once-daily ICV injections of OT led to the
development of tolerance to the inhibitory effects on food intake by the third day of treatment …