Objective—Diabetes mellitus causes vascular endothelial dysfunction and alters vascular
microRNA expression. We investigated whether endothelial microRNA-34a (miR-34a) leads
to diabetic vascular dysfunction by targeting endothelial sirtuin1 (Sirt1) and asked whether
the oxidative stress protein p66Shc governs miR-34a expression in the diabetic
endothelium. Approach and Results—MiR-34a is upregulated, and Sirt1 downregulated, in
aortic endothelium of db/db and streptozotocin-induced diabetic mice. Systemic …

Objective Diabetes mellitus causes vascular endothelial dysfunction and alters vascular
microRNA expression. We investigated if endothelial microRNA‐34a (miR‐34a) leads to
diabetic vascular dysfunction by targeting endothelial Sirtuin1 (Sirt1), and asked if the
oxidative stress protein p66Shc governs miR‐34a expression in the diabetic endothelium.
Approach and Results MiR‐34a is upregulated, and Sirt1down‐regulated, in aortic
endothelium of db/db and streptozotocin (STZ)‐induced diabetic mice. Systemic …