PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer
J Dupont Jensen, AV Laenkholm, A Knoop… - Clinical Cancer …, 2011 - AACR
Purpose: PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway.
Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In
a cohort of patients where both primary and metastatic lesions were available, the objective
was to assess changes in PIK3CA mutations. We wished to discern whether selective
pressures occur and the influence of PIK3CA mutation on time to recurrence. Experimental
Design: Formalin-fixed paraffin-embedded tumor blocks were obtained from 104 patients …
Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In
a cohort of patients where both primary and metastatic lesions were available, the objective
was to assess changes in PIK3CA mutations. We wished to discern whether selective
pressures occur and the influence of PIK3CA mutation on time to recurrence. Experimental
Design: Formalin-fixed paraffin-embedded tumor blocks were obtained from 104 patients …
[引用][C] PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer: Jensen JD, Laenkholm AV, Knoop A, et al …
GB Mills - Breast Diseases, 2011 - mdanderson.elsevierpure.com
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