PTBP1 and PTBP2 repress nonconserved cryptic exons
The fidelity of RNA splicing is maintained by a network of factors, but the molecular
mechanisms that govern this process have yet to be fully elucidated. We previously found
that TDP-43, an RNA-binding protein implicated in neurodegenerative disease, utilizes UG
microsatellites to repress nonconserved cryptic exons and prevent their incorporation into
mRNA. Here, we report that two well-characterized splicing factors, polypyrimidine tract-
binding protein 1 (PTBP1) and polypyrimidine tract-binding protein 2 (PTBP2), are also …
mechanisms that govern this process have yet to be fully elucidated. We previously found
that TDP-43, an RNA-binding protein implicated in neurodegenerative disease, utilizes UG
microsatellites to repress nonconserved cryptic exons and prevent their incorporation into
mRNA. Here, we report that two well-characterized splicing factors, polypyrimidine tract-
binding protein 1 (PTBP1) and polypyrimidine tract-binding protein 2 (PTBP2), are also …
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