Paclitaxel inhibits KCNQ channels in Primary sensory neurons to initiate the development of painful peripheral neuropathy
Z Wu, G Toro, G Xu, D Dang, C Prater, Q Yang - Cells, 2022 - mdpi.com
Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve
degeneration and serious neuropathic pain termed paclitaxel-induced peripheral
neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do
not eliminate PIPN, and no therapies are available for PIPN, despite numerous studies to
uncover the mechanisms underlying the development/maintenance of this condition.
Therefore, we aimed to uncover a novel mechanism underlying the pathogenesis of PIPN …
degeneration and serious neuropathic pain termed paclitaxel-induced peripheral
neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do
not eliminate PIPN, and no therapies are available for PIPN, despite numerous studies to
uncover the mechanisms underlying the development/maintenance of this condition.
Therefore, we aimed to uncover a novel mechanism underlying the pathogenesis of PIPN …
[PDF][PDF] Paclitaxel Inhibits KCNQ Channels in Primary Sensory Neurons to Initiate the Development of Painful Peripheral Neuropathy. Cells 2022, 11, 4067
Z Wu, G Toro, G Xu, D Dang, C Prater, Q Yang - 2022 - academia.edu
Cancer patients undergoing paclitaxel infusion usually experience peripheral nerve
degeneration and serious neuropathic pain termed paclitaxel-induced peripheral
neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do
not eliminate PIPN, and no therapies are available for PIPN, despite numerous studies to
uncover the mechanisms underlying the development/maintenance of this condition.
Therefore, we aimed to uncover a novel mechanism underlying the pathogenesis of PIPN …
degeneration and serious neuropathic pain termed paclitaxel-induced peripheral
neuropathy (PIPN). However, alterations in the dose or treatment schedule for paclitaxel do
not eliminate PIPN, and no therapies are available for PIPN, despite numerous studies to
uncover the mechanisms underlying the development/maintenance of this condition.
Therefore, we aimed to uncover a novel mechanism underlying the pathogenesis of PIPN …
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