Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt
personalized treatments, reduce overtreatment and improve outcomes. Here we describe
the largest, to our knowledge, pan-cancer study of metastatic solid tumour genomes,
including whole-genome sequencing data for 2,520 pairs of tumour and normal tissue,
analysed at median depths of 106× and 38×, respectively, and surveying more than 70 …

Background Metastatic cancer is one of the major causes of death and is associated with
poor treatment efficiency. A better understanding of the characteristics of late stage cancer is
required to help tailor personalised treatment, reduce overtreatment and improve outcomes.
Methods Here we describe the largest pan-cancer study of metastatic solid tumor genomes,
including 2,520 whole genome-sequenced tumor-normal pairs, analyzed at a median depth
of 106x and 38x respectively, and surveying over 70 million somatic variants. Results …