Abstract. Batistatou A, Zolota V, Tzoracoleftherakis E, Scopa CD. Papillary serous adenocarcinoma of the endocervix. A rare neoplasm. Immunohistochemical profile.

Serous adenocarcinoma of the endocervix is a rare carcinoma similar to the serous carcinoma of the ovary and the endometrium. We report a case of a 63‐year‐old woman with papillary serous adenocarcinoma arising within the endocervix, describing the clinical presentation and the morphologic characteristics of this rare neoplasm. A detailed immunohistochemical analysis on the expression of low‐ and high‐molecular weight cytokeratins (AE1 and AE3), EMA, CEA, vimentin, B72.3, nm23, estrogen and progesterone receptors, LeuM1 (CD15), p53, Ki‐67 antigen, and PCNA by tumor cells has also been carried out, which to our knowledge has not been previously reported.