This paper presents a 15-year-old boy with an acute febrile illness accompanied by purpuric
and papular lesions located mostly on the dorsal areas of his hands and feet with the
additional changes on his knees and elbows. Serologic studies confirmed the acute
infection by parvovirus B19. Apart from mild leukocytosis there were no other abnormalities
in hematologic and laboratory findings. The diagnosis of papular-purpuric" gloves and
socks" syndrome (PPGSS) was made. Cutaneous changes completely resolved two weeks …

Papular-purpuric" gloves and socks" syndrome (PPGSS) is a novel, rare, self-limiting
dermatosis caused by human parvovirus B19. It consists of pruritic edema and erythema of
the hands and feet in a gloves-and-socks distribution, and it is associated with oral lesions
and fever. We present a case of PPGSS in a 22-year-old Brazilian woman. Clinical and
laboratory evaluation, including serological tests, PCR and gene sequencing, confirmed the
presence of human parvovirus B19.