Steatosis has been reported to negatively influence the natural history of chronic hepatitis C
(CHC), but controversy remains over its causal role due to the confounding effect of
adiposity, insulin resistance, and diabetes. The rs738409 C> G patatin‐like phospholipase
domain‐containing 3 (PNPLA3) single nucleotide polymorphism (SNP), encoding for the
I148M protein variant, influences liver fat without affecting insulin resistance and body
composition. The aim of this study was to evaluate the effect of the rs738409 CG genotype …

AIM: To investigate whether the patatin-like phospholipase domain containing-3 gene
(PNPLA3) I148M polymorphism is associated with steatosis, fibrosis stage, and cirrhosis in
hereditary hemochromatosis (HH). METHODS: We studied 174 consecutive unrelated
homozygous for the C282Y HFE mutation of HH (C282Y+/+ HH) patients from Northern Italy,
for whom the presence of cirrhosis could be determined based on histological or clinical
criteria, without excessive alcohol intake (< 30/20 g/d in males or females) or hepatitis B …