Objective: Cushing disease is a rare severe condition caused by pituitary tumors that secrete
adrenocorticotropic hormone (ACTH), leading to excessive endogenous glucocorticoid
production. Tumors causing Cushing disease, also called corticotropinomas, are typically
monoclonal neoplasms that mainly occur sporadically. Methods: Literature review. Results:
Cushing disease is very rarely encountered in genetic familial syndromes. Oncogenes and
tumor suppressor genes commonly associated with other tumor types are only rarely …